Immunoediting, the loss of tumor (neo)antigens due to T cell-dependent selection, sculpts tumor immunogenicity. In Nature, Łuksza et al. conceive a model to score neoantigens’ immunogenicity and predict tumor clonal evolution. With this model, they demonstrate that durable tumor control associates with selective limited acquisition of high-quality mutations.

中文翻译：

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免疫压力塑造肿瘤细胞并消除高质量突变

免疫编辑，即由于 T 细胞依赖性选择而导致的肿瘤 ( neo ) 抗原的损失，塑造了肿瘤的免疫原性。在《自然》中，Łuksza 等人。构思一个模型来对新抗原的免疫原性进行评分并预测肿瘤克隆进化。通过这个模型，他们证明了持久的肿瘤控制与选择性有限获得高质量突变相关。