Aging-induced alternations of vasculature structures, phenotypes, and functions are key in the occurrence and development of vascular aging-related diseases. Multiple molecular and cellular events, such as oxidative stress, mitochondrial dysfunction, vascular inflammation, cellular senescence, and epigenetic alterations are highly associated with vascular aging physiopathology. Advances in nanoparticles and nanotechnology, which can realize sensitive diagnostic modalities, efficient medical treatment, and better prognosis as well as less adverse effects on non-target tissues, provide an amazing window in the field of vascular aging and related diseases. Throughout this review, we presented current knowledge on classification of nanoparticles and the relationship between vascular aging and related diseases. Importantly, we comprehensively summarized the potential of nanoparticles-based diagnostic and therapeutic techniques in vascular aging and related diseases, including cardiovascular diseases, cerebrovascular diseases, as well as chronic kidney diseases, and discussed the advantages and limitations of their clinical applications.

老化引起的血管结构、表型和功能的改变是血管老化相关疾病发生和发展的关键。多种分子和细胞事件，如氧化应激、线粒体功能障碍、血管炎症、细胞衰老和表观遗传改变与血管老化生理病理学高度相关。纳米粒子和纳米技术的进步，可以实现灵敏的诊断方式、高效的医疗、更好的预后以及对非靶组织的较少不良影响，为血管老化和相关疾病领域提供了一个惊人的窗口。在这篇综述中，我们介绍了当前关于纳米粒子分类以及血管老化与相关疾病之间关系的知识。重要的，