There is an increasing need to develop biological anti-inflammatory agents that are more targeted, effective, and with lesser side effects as compared to conventional chemical drugs. In the present study, we found that Mycobacterium tuberculosis protein PPE2 and a synthetic derivative peptide can suppress the mast cell population and inhibit several vasoactive and fibrogenic mediators and pro-inflammatory cytokines induced by mast cells in formalin-induced tissue injury. PPE2 was found to inhibit transcription from the promoter of stem cell factor, important for mast cell maintenance and migration. Thus, PPE2/peptide can be used as a potent nonsteroidal therapeutic agent for the treatment of inflammation and tissue injury.

中文翻译：

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结核分枝杆菌PPE2蛋白在抑制组织炎症中的治疗应用

与传统化学药物相比，越来越需要开发靶向性更强、更有效且副作用更小的生物抗炎剂。在本研究中，我们发现结核分枝杆菌蛋白 PPE2 和合成的衍生肽可以抑制肥大细胞群，并抑制肥大细胞在福尔马林诱导的组织损伤中诱导的多种血管活性和纤维化介质和促炎细胞因子。PPE2被发现抑制干细胞因子启动子的转录，这对肥大细胞的维持和迁移很重要。因此，PPE2/肽可用作治疗炎症和组织损伤的有效非甾体治疗剂。