GRN Mutations Are Associated with Lewy Body Dementia,Movement Disorders

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GRN Mutations Are Associated with Lewy Body Dementia
Movement Disorders ( IF 7.4 ) Pub Date : 2022-07-10 , DOI: 10.1002/mds.29144
Paolo Reho ₁ , Shunsuke Koga ₂ , Zalak Shah ₁ , Ruth Chia ₃ , , , Rosa Rademakers _{2,

4} , Clifton L Dalgard _{5,

6} , Bradley F Boeve ₇ , Thomas G Beach ₈ , Dennis W Dickson ₂ , Owen A Ross _{2,

9} , Sonja W Scholz _{1,

10}

Affiliation

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.
VIB Center for Molecular Neurology, Antwerp, Belgium.
Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
The American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Banner Sun Health Research Institute, Sun City, Arizona, USA.
Department of Clinical Genomics, Mayo Clinic, Jacksonville, Florida, USA.
Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.

Loss-of-function mutations in GRN are a cause of familial frontotemporal dementia, and common variants within the gene have been associated with an increased risk of developing Alzheimer's disease and Parkinson's disease. Although TDP-43-positive inclusions are characteristic of GRN-related neurodegeneration, Lewy body copathology has also been observed in many GRN mutation carriers.

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