The development of integrated continuous biomanufacturing processes faces a significant challenge when the parameters for the design of the process cannot be accurately estimated from those of batch experiments. Process design is even more challenging if the outcome of one unit operation highly influences the performance of the subsequent one, such as in harvesting of a precipitate by filtration. In the case of protein precipitation, results from the batch and continuous experiements deviate and their scale-down is limited. Microfluidics suffer from poor mixing characteristics. Thus, milliscale devices were developed to maintain mixing performance but at the expense of a slightly larger scale.

中文翻译：

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用于集成连续沉淀和过滤的毫级反应器

当无法从批量实验的参数中准确估计工艺设计参数时，集成连续生物制造工艺的开发面临重大挑战。如果一个单元操作的结果高度影响后续单元的性能，例如通过过滤收集沉淀物，则工艺设计更具挑战性。在蛋白质沉淀的情况下，批次和连续实验的结果会出现偏差，并且它们的按比例缩小是有限的。微流体具有较差的混合特性。因此，开发了毫尺度设备以保持混合性能，但以稍大的规模为代价。