To develop a predictable and reproducible model of knee osteoarthritis after medial meniscus posterior root release. Posteromedial meniscal root tears were created in 12 White New Zealand rabbit knees. The contralateral limbs were used as healthy controls. The animals were euthanized at 16 weeks postoperatively; tissue samples of femoral and tibial articular cartilage were collected and processed for macro and microscopic analyses to detect signs of early degeneration. Clinical evaluation of the weight-bearing status on the affected knee was conducted at 0-, 4-, 8-, and 16-weeks postoperatively. Early and severe osteoarthritic changes were the hallmark and the main findings after 16-weeks post-surgery. Macroscopically, extensive osteoarthritic changes were observed across the femoral condyle and tibial plateau. Microscopic finding included ulcerations, fissures, fibrillations, pitting, and loss of the superficial layer. Cellularity was diminished, the normal pattern of distribution in columns was lost, and subchondral bone exposure was also evident. This study describes a novel model of knee osteoarthritis that may guide the development of tailored interventions to delay or prevent knee osteoarthritis. This knowledge could shift the current treatment paradigm toward more conservative and knee salvageable treatment options and increase surgeons’ awareness of this injury pattern. Such considerations may have a positive impact on clinical decision-making and subsequent patient-reported clinical outcomes. Controlled laboratory study. II.

中文翻译：

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开发内侧半月板后根释放后早期膝关节骨性关节炎的实验模型：体内研究

开发内侧半月板后根释放后膝关节骨关节炎的可预测和可重复模型。在 12 只新西兰白兔膝盖中产生后内侧半月板根撕裂。对侧肢体用作健康对照。术后16周对动物实施安乐死；收集并处理股骨和胫骨关节软骨的组织样本进行宏观和微观分析，以检测早期退化的迹象。在术后 0、4、8 和 16 周对受影响膝关节的负重状态进行临床评估。早期和严重的骨关​​节炎变化是术后 16 周的标志和主要发现。宏观上，在股骨髁和胫骨平台上观察到广泛的骨关节炎变化。显微镜下发现包括溃疡、裂缝、纤颤、凹陷和表层缺失。细胞减少，柱状分布的正常模式消失，软骨下骨暴露也很明显。本研究描述了一种新型膝关节骨关节炎模型，可指导开发定制干预措施以延迟或预防膝关节骨关节炎。这种知识可以将当前的治疗模式转变为更保守和膝关节可挽救的治疗选择，并提高外科医生对这种损伤模式的认识。这些考虑可能对临床决策和随后的患者报告的临床结果产生积极影响。受控实验室研究。二、柱状分布的正常模式丢失，软骨下骨暴露也很明显。本研究描述了一种新型膝关节骨关节炎模型，可指导开发定制干预措施以延迟或预防膝关节骨关节炎。这种知识可以将当前的治疗模式转变为更保守和膝关节可挽救的治疗选择，并提高外科医生对这种损伤模式的认识。这些考虑可能对临床决策和随后的患者报告的临床结果产生积极影响。受控实验室研究。二、柱状分布的正常模式丢失，软骨下骨暴露也很明显。本研究描述了一种新型膝关节骨关节炎模型，可指导开发定制干预措施以延迟或预防膝关节骨关节炎。这种知识可以将当前的治疗模式转变为更保守和膝关节可挽救的治疗选择，并提高外科医生对这种损伤模式的认识。这些考虑可能对临床决策和随后的患者报告的临床结果产生积极影响。受控实验室研究。二、这种知识可以将当前的治疗模式转变为更保守和膝关节可挽救的治疗选择，并提高外科医生对这种损伤模式的认识。这些考虑可能对临床决策和随后的患者报告的临床结果产生积极影响。受控实验室研究。二、这种知识可以将当前的治疗模式转变为更保守和膝关节可挽救的治疗选择，并提高外科医生对这种损伤模式的认识。这些考虑可能对临床决策和随后的患者报告的临床结果产生积极影响。受控实验室研究。二、