OBJECTIVE We aimed to examine the dose-response associations between the number of steps per day and all-cause mortality among adults with prediabetes and diabetes. RESEARCH DESIGN AND METHODS This prospective study used data from 1,194 U.S. adults with prediabetes and 493 with diabetes for whom accelerometer-derived steps per day could be retrieved. Mortality was ascertained through the National Death Index (February 25, 2019). Splines were used to assess the dose-response associations between steps per day and all-cause mortality. RESULTS Over ∼9 years of follow-up, 200 adults with prediabetes and 138 with diabetes died. Nonlinear associations akin to an L shape were observed. We estimated an optimal dose of ∼10,000 steps per day to reduce the risk of all-cause mortality for both individuals with prediabetes and those with diabetes. CONCLUSIONS Accumulating more steps per day up to ∼10,000 steps per day may lower the risk of all-cause mortality of adults with prediabetes and diabetes.

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预防糖尿病前期和糖尿病患者全因死亡的最佳每日步数

目的：我们旨在研究糖尿病前期和糖尿病成人患者每日步数与全因死亡率之间的剂量反应关系。研究设 死亡率通过国家死亡指数（2019 年 2 月 25 日）确定。样条曲线用于评估每天步数与全因死亡率之间的剂量反应关联。结果 在 9 年的随访中，200 名患有前驱糖尿病的成年人和 138 名患有糖尿病的成年人死亡。观察到类似于 L 形的非线性关联。我们估计每天 10,000 步的最佳剂量可以降低糖尿病前期患者和糖尿病患者全因死亡的风险。