Valproate is widely used in psychiatry and neurology, including off-label use. Here we consider its potential benefits and risks, particularly for women of childbearing potential, and the evidence that clinical guidelines are adhered to. Finally, we consider the implications for clinical practice and research into its efficacy in off-label indications.

中文翻译：

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是时候重新评估丙戊酸盐的风险和益处并呼吁采取行动了

丙戊酸盐广泛用于精神病学和神经学，包括超适应症使用。在这里，我们考虑其潜在的好处和风险，特别是对有生育潜力的女性，以及遵守临床指南的证据。最后，我们考虑了对临床实践的影响以及对其在标签外适应症中疗效的研究。