An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis,Reaction Chemistry & Engineering

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An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2022-07-07 , DOI: 10.1039/d2re00153e
Hannes Westphal ₁ , Rico Warias ₁ , Chris Weise ₁ , Daniele Ragno ₂ , Holger Becker ₃ , Matthias Spanka ₄ , Alessandro Massi ₂ , Roger Gläser ₃ , Christoph Schneider ₄ , Detlev Belder ₁

Affiliation

A highly integrated microfluidic device is presented for the parallelised study of stereoselective heterogeneous catalytic processes. For the first time, multiple packed-bed μ-flow reactors are combined with a chiral separation unit on a chip that is seamlessly connected to mass spectrometry. By developing an automated fluidic setup, this device allows the performance of different catalysts to be studied in a single run, using only small amounts of resources. In this way, fully automated quasi-simultaneous testing of 2-packed bed reactors for enantioselectivity and conversion is possible, with a significant reduction in solvent and substrate consumption compared to classical tube reactor HPLC-MS testing.

中文翻译：

一种集成的资源节约型微流控装置，用于通过小型化 LC/MS 分析在连续流动中并行研究固定化手性催化剂

提出了一种高度集成的微流体装置，用于立体选择性多相催化过程的并行研究。多个填充床 μ 流反应器首次与芯片上的手性分离单元相结合，与质谱仪无缝连接。通过开发一种自动化的流体装置，该装置允许在一次运行中研究不同催化剂的性能，并且只使用少量资源。通过这种方式，可以对 2 填充床反应器的对映选择性和转化率进行全自动准同时测试，与经典管式反应器 HPLC-MS 测试相比，溶剂和底物消耗量显着降低。

更新日期：2022-07-12

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