Background Overminus lens is an effective non-surgical treatment of intermittent exotropia (IXT). Whether this treatment causes development of myopia is recently debated. This study evaluated ocular biometric changes in IXT children treated with and without overminus lens. Methods Children with IXT were randomly assigned to control and overminus groups. Cycloplegic refraction, axial length and other parameters (keratometry, anterior chamber depth and lens thickness) were evaluated for up to 30 months and compared between the groups. Axial length to corneal curvature (AL/CR) ratio was examined as an indicator of myopia progression. Changes prior to and after overminus were also assessed in a subgroup. Results Mean age of the total 84 subjects (58% women) was 7.2 years (range 4–15 years). Baseline refractive and biometric parameters of 39 control and 45 overminus subjects were not significantly different. Mean±SD change in refraction was −0.34±0.45D in controls and −0.41±0.66D in overminus group (p=0.527). AL increased by 0.29±0.20 millimetre (mm) in controls and 0.28±0.23 mm in overminus group (p=0.766). In the subgroup, the changes before and after overminus therapy was not significantly different (p>0.05). AL/CR ratio was maintained from baseline to follow-up visit (p=0.298) in both groups. Conclusion No significant differences in biometry or refraction were found between the two groups and before and after the therapy. We conclude that the overminus therapy in children, not accounting for other myopia risk factors, does not affect normal refractive growths. Data are available upon reasonable request. Data may be obtained from a third party and are not publicly available. Data available on request.

中文翻译：

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使用和不使用超减晶状体治疗的间歇性外斜视生物特征和屈光变化的比较

背景 Overminus 晶状体是间歇性外斜视 (IXT) 的有效非手术治疗方法。这种治疗是否会导致近视的发展最近存在争议。本研究评估了使用或不使用超减镜片治疗的 IXT 儿童的眼部生物特征变化。方法 IXT 儿童被随机分为对照组和超减组。对散瞳验光、眼轴长度和其他参数（角膜曲率、前房深度和晶状体厚度）进行长达 30 个月的评估，并在各组之间进行比较。检查眼轴长度与角膜曲率（AL/CR）的比率作为近视进展的指标。还在一个亚组中评估了超减之前和之后的变化。结果 84 名受试者（58% 为女性）的平均年龄为 7.2 岁（范围 4-15 岁）。39 名对照组和 45 名超减受试者的基线屈光和生物特征参数没有显着差异。对照组的平均±SD屈光变化为-0.34±0.45D，超减组的屈光变化为-0.41±0.66D（p=0.527）。对照组的 AL 增加了 0.29±0.20 毫米 (mm)，超减组的 AL 增加了 0.28±0.23 毫米 (p=0.766)。在该亚组中，过度治疗前后的变化没有显着差异（p>0.05）。两组的 AL/CR 比率从基线到随访均保持不变 (p=0.298)。结论 两组之间以及治疗前后生物测量或屈光度均无显着差异。我们的结论是，在不考虑其他近视危险因素的情况下，儿童的过度减视治疗不会影响正常的屈光生长。数据可根据合理要求提供。数据可能从第三方获得，并且不公开。可根据要求提供数据。