This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, ) and Suita score (r = 0.291, ). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, ), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, ). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, ; β = 2.994, ; β = 0.139, ; and β = 0.265, , respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes.

中文翻译：

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Fibrosis-4 指数与 2 型糖尿病患者的动脉损伤和未来患冠心病的风险密切相关

本研究评估了 fibrosis-4 (FIB 4) 指数与 2 型糖尿病患者动脉损伤或未来冠心病 (CHD) 风险之间的关联。研究对象为 253 名 2 型糖尿病患者。计算所有受试者的 FIB4 指数，作为基于年龄、天冬氨酸氨基转移酶和丙氨酸氨基转移酶水平以及血小板计数的肝纤维化标志物。颈动脉内膜中层厚度 (IMT)、颈动脉钙化 (CAC) 和主动脉弓钙化 (AAC) 等级 (0-2) 被评估为动脉粥样硬化变量。Suita 评分被计算为未来患冠心病 (CHD) 的风险。我们评估了 FIB4 指数是否与动脉粥样硬化变量和 Suita 评分相关。FIB4 指数与 IMT 显着相关 ( r  = 0.241,)和吹田分数 ( r  = 0.291,）。与没有 CAC 的受试者相比，有 CAC 的受试者的 FIB4 指数得分显着更高（分别为 1.70 ± 0.74 和 1.24 ± 0.69，)，而 FIB4 指数随着 AAC 等级的升高而显着升高（分别为 1.24 ± 0.74、1.56 ± 0.66 和 1.79 ± 0.71，）。调整临床特征的线性回归分析表明，FIB4 指数与 IMT、Suita 评分、CAC 和 AAC 分级呈正相关（ β  = 0.241，; β  = 2.994，; β  = 0.139，; 和β  = 0.265，，分别）。FIB4 指数与 2 型糖尿病患者的动脉损伤和未来发生 CHD 的风险密切相关。