Guideline-directed medical therapy in patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation,European Journal of Heart Failure

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Guideline-directed medical therapy in patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2022-07-06 , DOI: 10.1002/ejhf.2613
Satoshi Higuchi ₁ , Mathias Orban _{1,

2} , Marianna Adamo ₃ , Cristina Giannini ₄ , Bruno Melica ₅ , Nicole Karam ₆ , Fabien Praz ₇ , Daniel Kalbacher _{8,

9} , Benedikt Koell ₈ , Lukas Stolz ₁ , Daniel Braun _{1,

2} , Michael Näbauer ₁ , Mirjam Wild _{1,

7} , Philipp Doldi _{1,

2} , Michael Neuss ₁₀ , Christian Butter ₁₀ , Mohammad Kassar ₇ , Tobias Ruf ₁₁ , Aniela Petrescu ₁₁ , Sebastian Ludwig ₈ , Roman Pfister ₁₂ , Christos Iliadis ₁₂ , Matthias Unterhuber ₁₃ , Francisco Sampaio ₅ , Diogo Ferreira ₅ , Holger Thiele ₁₃ , Stephan Baldus ₁₂ , Ralph Stephan von Bardeleben ₁₁ , Steffen Massberg _{1,

2} , Stephan Windecker ₇ , Philipp Lurz ₁₃ , Anna Sonia Petronio ₄ , JoAnn Lindenfeld ₁₄ , William T Abraham ₁₅ , Marco Metra ₃ , Jörg Hausleiter _{1,

2} ,

Affiliation

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany.
Munich Heart Alliance, Partner Site German Center for Cardiovascular Disease (DZHK), Munich, Germany.
Cardiac Catheterization Laboratory and Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, University of Pisa, Pisa, Italy.
Cardiology Department, Centro Hospitalar Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal.
Paris University, PARCC, INSERM, F-75015, European Hospital Georges Pompidou, Paris, France.
Universitätsklinik für Kardiologie, Inselspital Bern, Bern, Switzerland.
Universitäres Herz- und Gefäßzentrum Hamburg, Klinik für Kardiologie, Hamburg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany.
Herzzentrum Brandenburg, Medizinische Hochschule Brandenburg Theodor Fontane, Bernau, Germany.
Zentrum für Kardiologie, Johannes Gutenberg-Universität, Mainz, Germany.
Department III of Internal Medicine, Heart Center, University of Cologne, Cologne, Germany.
Department of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Department of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.

Guideline-directed medical therapy (GDMT), based on the combination of beta-blockers (BB), renin–angiotensin system inhibitors (RASI), and mineralocorticoid receptor antagonists (MRA), is known to have a major impact on the outcome of patients with heart failure with reduced ejection fraction (HFrEF). Although GDMT is recommended prior to mitral valve transcatheter edge-to-edge repair (M-TEER), not all patients tolerate it. We studied the association of GDMT prescription with survival in HFrEF patients undergoing M-TEER for secondary mitral regurgitation (SMR).

中文翻译：

接受经导管边对边修复术治疗继发性二尖瓣反流患者的指南指导药物治疗

以 β 受体阻滞剂 (BB)、肾素-血管紧张素系统抑制剂 (RASI) 和盐皮质激素受体拮抗剂 (MRA) 联合为基础的指南指导药物治疗 (GDMT) 已知对患者的预后有重大影响伴有射血分数降低的心力衰竭 (HFrEF)。尽管在二尖瓣经导管边缘修复术 (M-TEER) 之前推荐 GDMT，但并非所有患者都能耐受。我们研究了 GDMT 处方与接受 M-TEER 治疗继发性二尖瓣反流 (SMR) 的 HFrEF 患者生存的关联。

更新日期：2022-07-06

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