Obesity-induced type 2 diabetes, or diabesity, is associated with ER stress, UPR activation, and insulin resistance through poorly understood mechanisms. Herrema et al. (2022) report that the XBP1 target FKBP11 is repressed in the obese mouse liver and that its re-expression activates a protective UPR pathway that restores insulin sensitivity.

中文翻译：

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糖尿病？不用担心，FKBP11 来救援

肥胖引起的 2 型糖尿病或糖尿病通过知之甚少的机制与 ER 应激、UPR 激活和胰岛素抵抗有关。Herrema 等人。(2022) 报告称，XBP1 靶标 FKBP11 在肥胖小鼠肝脏中受到抑制，并且其重新表达激活了保护性 UPR 通路，从而恢复了胰岛素敏感性。