Wound complications are common after resection of soft tissue sarcomas, with published infection rates ranging from 10% to 35%. Multiple studies have reported on the atypical flora comprising these infections, which are often polymicrobial and contain anaerobic bacteria, and recent studies have noted the high prevalence of anaerobic bacterial infections after soft tissue sarcoma resection [26, 35]. Based on this, our institution changed clinical practice to include an antibiotic with anaerobic coverage in addition to the standard first-generation cephalosporin for prophylaxis during soft tissue sarcoma resections. The current study was undertaken to evaluate whether this change was associated with a change in major wound complications, and if the change should therefore be adopted for future patients.

中文翻译：

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软组织肉瘤切除术期间在围手术期抗生素预防中增加厌氧菌覆盖是否与伤口并发症比例的减少有关？

软组织肉瘤切除术后伤口并发症很常见，已发表的感染率在 10% 至 35% 之间。多项研究报告了包含这些感染的非典型菌群，这些感染通常是多种微生物并含有厌氧菌，最近的研究指出软组织肉瘤切除术后厌氧菌感染的患病率很高[26, 35]。基于此，我们的机构改变了临床实践，除了标准的第一代头孢菌素之外，还添加了厌氧菌覆盖的抗生素，用于软组织肉瘤切除术期间的预防。目前的研究旨在评估这种变化是否与主要伤口并发症的变化相关，以及是否应该在未来的患者中采用这种变化。