Purpose

Examine SARS-CoV-2 seroprevalence and the association of seropositivity with demographic, geographic, and behavioral variables among University of North Carolina Chapel Hill (UNC-CH) undergraduate students enrolled in the fall 2020 semester.

Methods

All UNC-CH undergraduate students were invited to participate in the Heelcheck study; participants were weighted to the UNC-CH undergraduate population using raking methods. We estimate SARS-CoV-2 seroprevalence at study entrance (11/12/2020–12/10/2020) and bivariable associations using log-binomial regression.

Results

SARS-CoV-2 seroprevalence was 7.3% (95% confidence interval (CI): 5.4%–9.2%) at baseline. Compared to students who were living off-campus in the Chapel Hill/Carrboro area (CH) for the Fall 2020 semester (8.6% seroprevalence), students who never returned to CH had lower seroprevalence (1.9%, prevalence ratio (PR), 95% CI: 0.22, 0.06–0.81), whereas, students who started the semester on-campus and moved to off-campus CH housing had 18.9% seroprevalence (PR, 95% CI: 2.21, 1.04–4.72) and students who spent the semester living in a Sorority/Fraternity house had 46.8% seroprevalence (PR, 95% CI: 5.47, 2.62–11.46). Those who predicted they would join an indoor party unmasked had 3.8 times the seroprevalence of those who indicated they would not attend (PR, 95% CI: 3.80, 1.58–9.16). Compared to students who disagreed with the statement “…I am not going to let COVID-19 stop me from having fun…”, those who agreed had higher seroprevalence (14.0% vs. 5.7%; (PR, 95% CI: 2.45, 1.13–5.32)).

Discussion

Increased seroprevalence was associated with congregate living and participation (actual or endorsed) in social activities. During pandemics, universities must create safe socializing opportunities while minimizing transmission.

中文翻译：

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SARS-CoV-2 血清阳性率：与大学环境中大学生血清阳性相关的人口统计学和行为因素

 目的

检查 2020 年秋季学期入学的北卡罗来纳大学教堂山分校 (UNC-CH) 本科生的 SARS-CoV-2 血清阳性率以及血清阳性率与人口、地理和行为变量之间的关系。

 方法

所有 UNC-CH 本科生均被邀请参加 Heelcheck 研究；使用排名法对参与者进行加权，以计算 UNC-CH 本科生人口的权重。我们使用对数二项式回归估计了研究开始时（11/12/2020-12/10/2020）的 SARS-CoV-2 血清流行率和双变量关联。

 结果

基线时 SARS-CoV-2 血清阳性率为 7.3%（95% 置信区间 (CI)：5.4%–9.2%）。与 2020 年秋季学期住在教堂山/卡伯勒地区 (CH) 校外的学生 (8.6% 血清阳性率) 相比，从未返回 CH 的学生血清阳性率较低 (1.9%，患病率 (PR)，95 % CI: 0.22, 0.06–0.81)，而在校内开始学期并搬到校外 CH 宿舍的学生的血清阳性率为 18.9% (PR, 95% CI: 2.21, 1.04–4.72)住在联谊会/兄弟会宿舍的一个学期的血清阳性率为 46.8%（PR，95% CI：5.47，2.62–11.46）。那些预测自己会不戴口罩参加室内聚会的人的血清阳性率是那些表示不会参加的人的 3.8 倍（PR，95% CI：3.80，1.58-9.16）。与不同意“……我不会让 COVID-19 阻止我享受乐趣……”这一说法的学生相比，同意的学生血清阳性率更高（14.0% vs. 5.7%；（PR，95% CI：2.45， 1.13–5.32))。

 讨论

血清阳性率的增加与集体生活和参与（实际或认可的）社会活动有关。在大流行期间，大学必须创造安全的社交机会，同时尽量减少传播。