Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to the brain-invading tumor cells that remain following surgery within functioning brain regions. Developing therapies that can either directly target these brain-invading tumor cells or act on other cell types and molecular processes supporting tumor cell invasion and recurrence are essential steps in advancing new treatments in the clinic. This review highlights some of the drug delivery strategies and nanotherapeutic technologies that are designed to target brain-invading GBM cells or non-neoplastic, invasion-supporting cells residing within the GBM tumor microenvironment.

胶质母细胞瘤（GBM）是最常见的恶性成人脑癌，没有治愈性治疗策略。 GBM 治疗的一个重大障碍是向手术后仍保留在功能大脑区域内的侵入大脑的肿瘤细胞提供有效的治疗。开发可以直接针对这些脑侵袭性肿瘤细胞或作用于支持肿瘤细胞侵袭和复发的其他​​细胞类型和分子过程的疗法，是在临床上推进新疗法的重要步骤。这篇综述重点介绍了一些药物输送策略和纳米治疗技术，这些策略和纳米治疗技术旨在针对大脑侵袭性 GBM 细胞或 GBM 肿瘤微环境中的非肿瘤性侵袭支持细胞。