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Neurogenic–angiogenic synchrony via lactate
Nature Neuroscience ( IF 25.0 ) Pub Date : 2022-07-04 , DOI: 10.1038/s41593-022-01111-8
Daniel Z Doyle 1, 2, 3 , Kenneth Y Kwan 1, 2, 3
Affiliation  

During cortical development, the generation of neurons from progenitors coincides with increasing vascularization and oxygen levels in the fetal brain and the transition from anaerobic to aerobic metabolism. Dong et al. identify lactate, a metabolite of anaerobic glycolysis, as a multifunctional regulator that coordinates synchrony of cortical neurogenesis and angiogenesis.

中文翻译:

通过乳酸的神经源 - 血管生成同步

在皮层发育过程中,来自祖细胞的神经元的产生与胎儿大脑中血管化和氧气水平的增加以及从无氧代谢到有氧代谢的转变相吻合。董等人。确定乳酸,一种无氧糖酵解的代谢物,作为协调皮质神经发生和血管生成同步的多功能调节剂。
更新日期:2022-07-04
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