Drug combinations predicted to increase tumor cell death directly and by creating strong antitumor tumor microenvironments were identified by computational analysis of local responses to combinations of anticancer drugs delivered inside a tumor. Such predicted drug combinations were highly effective when administered systemically in mouse models of breast cancer.

中文翻译：

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确定增强肿瘤微环境介导的治疗反应的药物组合

通过对肿瘤内递送的抗癌药物组合的局部反应的计算分析，确定了预测会直接增加肿瘤细胞死亡并通过产生强大的抗肿瘤肿瘤微环境的药物组合。当在乳腺癌小鼠模型中全身给药时，这种预测的药物组合非常有效。