Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial,European Journal of Heart Failure

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Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2022-07-03 , DOI: 10.1002/ejhf.2602
Alberto Domínguez-Rodríguez _{1,

2} , Coral Suero-Mendez ₃ , Guillermo Burillo-Putze ₄ , Victor Gil ₅ , Rafael Calvo-Rodriguez ₆ , Pascual Piñera-Salmeron ₇ , Pere Llorens ₈ , Francisco J Martín-Sánchez ₉ , Pedro Abreu-Gonzalez ₁₀ , Òscar Miró ₅ ,

Affiliation

Department of Cardiology, Hospital Universitario de Canarias, Universidad Europea de Canarias, Tenerife, Spain.
CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Hospital de la Axarquía, Málaga, Spain.
Emergency Department, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain.
Emergency Department, Hospital Clinic, Barcelona, Institut d'Investigació Biomèdica August Pi iSunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Emergency Department, Hospital Universitario Reina Sofia, Córdoba, Spain.
Emergency Department, Hospital General Universitario Reina Sofía, Murcia, Spain.
Emergency Department, Short-Stay Unit and Home Hospitalization, Hospital General de Alicante, Alicante, Spain.
Emergency Department, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
Department of Physiology, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain.

Benzodiazepines have been used as safe anxiolytic drugs for decades and some authors have suggested they could be an alternative for morphine for treating acute cardiogenic pulmonary oedema (ACPE). We compared the efficacy and safety of midazolam and morphine in patients with ACPE.

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