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Feasibility and efficacy of a remotely delivered fall prevention exercise program for community-dwelling older adults with cancer: Protocol for the STABLE trial
Journal of Geriatric Oncology ( IF 3.0 ) Pub Date : 2022-07-02 , DOI: 10.1016/j.jgo.2022.06.009
Schroder Sattar 1 , Kristen R Haase 2 , Shabbir M H Alibhai 3 , Kelly Penz 1 , Michael Szafron 4 , Sebastian Harenberg 5 , Eitan Amir 6 , Shawn Kuster 7 , Eric Pitters 8 , Diane Campbell 9 , Margaret L McNeely 10
Affiliation  

Falls are a major issue in older adults with cancer due to the effects of cancer and its treatments. Ample evidence in the general population of older adults has demonstrated the effectiveness of strength and balance training in reducing fall rates in older adults. However, data on effective fall prevention interventions in the oncology setting are lacking. The objective of this study is to evaluate the feasibility and efficacy of a remotely delivered, partially-supervised, resistance and balance training program on lower body strength, balance, and falls in community-dwelling older adults with cancer. The proposed study is an observer-blinded, parallel group (intervention group vs. control group) randomized controlled trial (ClinicalTrials.gov Identifier: NCT04518098). This study will recruit 74 eligible community-dwelling older adults with cancer from a comprehensive cancer centre. Intervention includes a remotely delivered exercise program for 3 months. Outcome measures include feasibility measures, lower body strength, balance, and fall rates. Research ethics approval has been granted by the Biomedical Research Ethics Boards of the University of Saskatchewan. If found effective, findings from this study will inform a subsequent, phase III definitive trial, with the ultimate goal to reduce falls and reduce impact on cancer treatment. Study findings will be disseminated through presentation at community level and scientific conferences, and in scientific journals.

Trial registration: ClinicalTrials.gov identifier: NCT04518098



中文翻译:

针对社区居住的老年癌症患者远程实施的跌倒预防锻炼计划的可行性和有效性:STABLE 试验方案

由于癌症及其治疗的影响,跌倒是患有癌症的老年人的主要问题。一般老年人群中的大量证据表明力量和平衡训练在降低老年人跌倒率方面的有效性。然而,缺乏在肿瘤学环境中有效预防跌倒干预的数据。本研究的目的是评估远程交付、部分监督的阻力和平衡训练计划对社区居住的患有癌症的老年人的下半身力量、平衡和跌倒的可行性和有效性。拟议的研究是观察员盲法、平行组(干预组与对照组)随机对照试验(ClinicalTrials.gov 标识符:NCT04518098)。本研究将从一家综合性癌症中心招募 74 名符合条件的居住在社区的患有癌症的老年人。干预措施包括为期 3 个月的远程交付锻炼计划。结果测量包括可行性测量、下半身力量、平衡和跌倒率。萨斯喀彻温大学生物医学研究伦理委员会已批准研究伦理。如果发现有效,该研究的结果将为随后的 III 期最终试验提供信息,最终目标是减少跌倒并减少对癌症治疗的影响。研究结果将通过在社区层面和科学会议以及科学期刊上的展示来传播。结果测量包括可行性测量、下半身力量、平衡和跌倒率。萨斯喀彻温大学生物医学研究伦理委员会已批准研究伦理。如果发现有效,该研究的结果将为随后的 III 期最终试验提供信息,最终目标是减少跌倒并减少对癌症治疗的影响。研究结果将通过在社区层面和科学会议以及科学期刊上的展示来传播。结果测量包括可行性测量、下半身力量、平衡和跌倒率。萨斯喀彻温大学生物医学研究伦理委员会已批准研究伦理。如果发现有效,该研究的结果将为随后的 III 期最终试验提供信息,最终目标是减少跌倒并减少对癌症治疗的影响。研究结果将通过在社区层面和科学会议以及科学期刊上的展示来传播。最终目标是减少跌倒并减少对癌症治疗的影响。研究结果将通过在社区层面和科学会议以及科学期刊上的展示来传播。最终目标是减少跌倒并减少对癌症治疗的影响。研究结果将通过在社区层面和科学会议以及科学期刊上的展示来传播。

试验注册:ClinicalTrials.gov 标识符:NCT04518098

更新日期:2022-07-02
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