An updated hip fracture incidence rate for Brazil: the Brazilian Validation Osteoporosis Study (BRAVOS),Archives of Osteoporosis

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An updated hip fracture incidence rate for Brazil: the Brazilian Validation Osteoporosis Study (BRAVOS)
Archives of Osteoporosis ( IF 3.1 ) Pub Date : 2022-07-02 , DOI: 10.1007/s11657-022-01127-4
Ben-Hur Albergaria _{1,

2} , Cristiano A F Zerbini ₃ , Vera Lucia Szejnfeld ₄ , Sergio Ragi Eis ₁ , Dalisbor Marcelo Weber Silva ₅ , Maria de Fatima Lobato da Cunha ₆ , Michael R McClung ₇ , John A Kanis _{8,

9} , Eugene V McCloskey _{8,

10} , Tatiane Vilaca ₁₁ , Marise Lazaretti-Castro ₄

Affiliation

Summary

Hip fracture incidence rates in three representative geographic areas in Brazil over a period of 2 years (2010–2012) were assessed for the first time. Estimated incidence rates varied regionally, and markedly differed from those previously reported. Thus, national guidelines as well as FRAX Brazil should be revised in light of this new data.

Purpose

To determine the annual incidence of hip fractures in individuals aged 50 years and over, living in 3 cities located in different regions of the country. To investigate the age, gender, and regional differences in fracture rates. Based on the obtained data, to estimate the national incidence of hip fractures resulting from osteoporosis, in order to improve prevention strategies.

Methods

Retrospective, observational study including all patients aged ≥ 50 years admitted in hospitals because of a hip fracture in three cities (Belem, Joinville, and Vitoria) from representative geographic areas in Brazil from 2010 to 2012. Data were obtained from medical records in those cities. We analyzed incidence rates (crude and age- and gender-standardized rates) for hip fractures.

Results

There were 1025 (310 in men and 715 in women) hip fractures in the over 50-year-old merged population from the three cities. The crude incidence rate for hip fracture was 103.3/100,000 (95% confidence interval [CI = 97.0; 109.7), in men 77.4/100,000 (95% CI = 68.8; 86.0), and in women 125.2/100,000 (95% CI = 116.0; 134.4). Incidence standardized for age and gender was 105.9 cases per 100,000 persons per year (95% CI = 99.4; 112.4); 78.5 cases per 100,000 (95% CI = 69.8; 87.3) in men and 130.6 cases 100,000 in women (95% CI = 121.0, 140.2) per year. Belem, located in the equatorial region (latitude 1° 27′ S), had significantly lower crude and age-adjusted incidence than Joinville (latitude 26° 18′ S) and Vitoria (latitude 20° 19′ S), which were no different from each other. The incidence of fractures increased exponentially with age, and women had about twice the risk of fractures than men.

Conclusions

Hip fracture mainly affects elderly women and presents great variability in incidence between the different regions in Brazil. The incidence of hip fractures in Brazil differed markedly from that reported previously, so that national guidelines and the FRAX model for Brazil should be revised.

中文翻译：

巴西最新的髋部骨折发病率：巴西骨质疏松症验证研究 (BRAVOS)

概括

首次评估了 2 年（2010-2012 年）期间巴西三个代表性地理区域的髋部骨折发生率。估计的发病率因地区而异，并且与之前报道的明显不同。因此，应根据这些新数据修订国家指南和 FRAX 巴西。

目的

确定居住在该国不同地区的 3 个城市的 50 岁及以上人群的髋部骨折年发病率。调查骨折发生率的年龄、性别和地区差异。根据获得的数据，估计全国因骨质疏松症导致的髋部骨折的发生率，以改进预防策略。

方法

回顾性观察性研究，包括 2010 年至 2012 年在巴西代表性地理区域的三个城市（贝伦、若因维尔和维多利亚）因髋部骨折入院的所有年龄≥50 岁的患者。数据来自这些城市的医疗记录. 我们分析了髋部骨折的发生率（粗率和年龄和性别标准化率）。

结果

三市50岁以上人群合并髋部骨折1025例（男310例，女715例）。髋部骨折的粗发病率为 103.3/100,000（95% 置信区间 [CI = 97.0；109.7），男性为 77.4/100,000（95% CI = 68.8；86.0），女性为 125.2/100,000（95% CI = 116.0；134.4）。按年龄和性别标准化的发病率为每年每 100,000 人 105.9 例（95% CI = 99.4；112.4）；男性每年每 100,000 人 78.5 例（95% CI = 69.8；87.3），女性每年每 100,000 人 130.6 例（95% CI = 121.0，140.2）。位于赤道地区（南纬 1°27′）的贝伦（Belem）的粗发病率和年龄调整后发病率显着低于茹安维尔（南纬 26°18′）和维多利亚（南纬 20°19′），两者没有什么不同从彼此。随着年龄的增长，骨折的发生率呈指数增长，