Background and Aims: Diabetic nephropathy is one of the most important complications of diabetes mellitus. Recently, it has been reported that diabetics with sarcopenia have a high incidence of nephropathy. Five times sit-to-stand was developed as a measure of lower extremity strength, but it has been evaluated as physical function. However, the association between of physical function with microalbuminuria has been still unknown. Thus, we evaluated five times sit-to-stand and investigated its association with microalbuminuria in a cross-sectional study. Materials and Methods: This cross-sectional study recruited T2DM patients attending Ayabe City Hospital. Urinary albumin-to-creatinine ratio (UACR) was obtained by spot urine exams. We assessed the association of five times sit-to-stand with log UACR with linear regression model. In the multivariate model, we used age, gender, height, skeletal muscle mass, grip strength, body fat mass, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, smoking status and alcohol as co-variates. Results: Among 4patients (269 men, 66.4 %) , mean age, body mass index, hemoglobin A1c, five times sit-to-stand, and median UACR were 68.5 ± 11.1 years, 23.7 ± 3.8 kg/m2, 7.1 ± 0.8 %, 8.4 ± 2.2 seconds, and 12.7 mg/gCr respectively. Log UACR was associated with five times sit-to-stand in an univariate model (r = 0.19, P < 0.001) , and in a multivariate model (ß = 0.12, P = 0.035) . Conclusion: Five times sit-to-stand was associated with UACR in Japanese patients with type 2 diabetes. The important relationship between physical function and diabetic nephropathy was shown. Further research is needed to determine whether maintaining physical function can prevent the progression of diabetic nephropathy. Disclosure T.Osaka: n/a. M.Fukui: None. H.Fukui: None.

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1478-PUB：2 型糖尿病患者的五次坐姿与微量白蛋白尿相关：一项横断面研究

背景与目的：糖尿病肾病是糖尿病最重要的并发症之一。近期有报道称，患有肌肉减少症的糖尿病患者肾病发病率较高。五次从坐到站被开发为衡量下肢力量的方法，但它已被评估为身体功能。然而，身体机能与微量白蛋白尿之间的关联仍然未知。因此，我们在一项横断面研究中评估了五次从坐到站并调查其与微量白蛋白尿的关系。材料和方法：这项横断面研究招募了在绫部市医院就诊的 T2DM 患者。尿白蛋白与肌酐比值 (UACR) 通过现场尿液检查获得。我们使用线性回归模型评估了五次坐立与 log UACR 的关联。在多变量模型中，我们使用年龄、性别、身高、骨骼肌质量、握力、体脂肪量、收缩压、舒张压、血红蛋白 A1c、吸烟状况和酒精作为协变量。结果：在 4 名患者（269 名男性，66.4 %）中，平均年龄、体重指数、血红蛋白 A1c、5 次坐站和中位 UACR 分别为 68.5 ± 11.1 岁、23.7 ± 3.8 kg/m2、7.1 ± 0.8 % 、8.4 ± 2.2 秒和 12.7 mg/gCr 分别。在单变量模型 (r = 0.19, P < 0.001) 和多变量模型 (ß = 0.12, P = 0.035) 中，Log UACR 与五次坐立相关。结论：5 次坐立式与日本 2 型糖尿病患者的 UACR 相关。显示了身体机能与糖尿病肾病之间的重要关系。需要进一步的研究来确定维持身体机能是否可以预防糖尿病肾病的进展。披露东京：不适用。M.Fukui：没有。H.Fukui：没有。