Objectives: Accelerated atherogenesis can be defined as a complex procedure where the addition of facilitatory and pathogenic factors activates molecular pathways leading to the development and progression of atherosclerotic plaque. Patients diagnosed with Type-1 Diabetes bring control over the amount of sodium they consume. Despite the fact that salt intake is corresponding with blood pressure, it also partly determines the activation state of the RAAS. This study aims to determine the relationship between sodium intake and adverse outcomes among patients with diabetes. Methods: A total of 912 participants who regard their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Results: This study found that in adults with Type-1 diabetes, low sodium intake was connected with increased risks of new-onset cardiovascular events and all-cause mortality. High sodium intake was often blamed for drastic outcomes, which leads to a “J-shaped relationship” overall. Even though BP-lowering is considerably a crucial objective for the management of diabetes, off-target actions that would help in activating the RAAS might contribute to lack of protection from CVD complications among patients with Type-1 diabetes with low levels of sodium intake. Conclusion: This study suggested that the relationship between cardiovascular outcomes in diabetes and the amount of sodium intake is more complicated than simply being a cause of high BP. Disclosure S.Kumar: None.

中文翻译：

---

1480-PUB：1 型糖尿病中钠摄入量与动脉粥样硬化形成的关系

目标：加速动脉粥样硬化可以定义为一个复杂的过程，其中添加促进和致病因素激活导致动脉粥样硬化斑块发展和进展的分子途径。被诊断患有 1 型糖尿病的患者可以控制他们摄入的钠量。尽管盐摄入量与血压相对应，但它也部分决定了 RAAS 的激活状态。本研究旨在确定糖尿病患者钠摄入量与不良结局之间的关系。方法：通过基于食物组的食物频率问卷对总共 912 名在基线时考虑其饮食摄入量的参与者进行分析和评估。结果：本研究发现，在患有 1 型糖尿病的成年人中，低钠摄入与新发心血管事件和全因死亡率的风险增加有关。高钠摄入量经常被归咎于剧烈的结果，这导致了总体上的“J型关系”。尽管降压是糖尿病管理的一个重要目标，但有助于激活 RAAS 的脱靶行动可能会导致钠摄入量低的 1 型糖尿病患者对 CVD 并发症缺乏保护。结论：本研究表明，糖尿病心血管结局与钠摄入量之间的关系比单纯作为高血压的原因更为复杂。披露 S.Kumar：没有。这导致了总体上的“J型关系”。尽管降压是糖尿病管理的一个重要目标，但有助于激活 RAAS 的脱靶行动可能会导致钠摄入量低的 1 型糖尿病患者对 CVD 并发症缺乏保护。结论：本研究表明，糖尿病心血管结局与钠摄入量之间的关系比单纯作为高血压的原因更为复杂。披露 S.Kumar：没有。这导致了总体上的“J型关系”。尽管降压是糖尿病管理的一个重要目标，但有助于激活 RAAS 的脱靶行动可能会导致钠摄入量低的 1 型糖尿病患者对 CVD 并发症缺乏保护。结论：本研究表明，糖尿病心血管结局与钠摄入量之间的关系比单纯作为高血压的原因更为复杂。披露 S.Kumar：没有。结论：本研究表明，糖尿病心血管结局与钠摄入量之间的关系比单纯作为高血压的原因更为复杂。披露 S.Kumar：没有。结论：本研究表明，糖尿病心血管结局与钠摄入量之间的关系比单纯作为高血压的原因更为复杂。披露 S.Kumar：没有。