The GnRH antagonist protocol has become increasingly popular for ovarian stimulation (OS), thanks to a number of advantages over the long GnRH agonist protocol: a reduced duration of stimulation with lower consumption of gonadotrophins and a lower rate of the ovarian hyperstimulation syndrome (OHSS), without any compromise in delivery rates. Despite the clear benefits associated with the GnRH antagonist protocol, the long GnRH agonist protocol allows a more flexible and controlled schedule of oocyte retrievals: this is important both for the patient, who wants to undergo reproductive treatment at her own convenience, and for the IVF clinic. Cycle scheduling allows not only a more equal distribution of the work load, but can also avoid the vast majority of oocyte retrievals during weekend days. To circumvent this shortcoming, the use of oral contraceptive pills (OCP) has been advocated as a programming method for IVF cycles using the GnRH antagonist protocol. Although the published evidence is clear about the negative impact of this method of programming, it is still widely used over the globe. Nevertheless, there are other possibilities of scheduling the oocyte retrievals, such as the use of estradiol, a pretreatment of GnRH antagonists, and other approaches. These options will be highlighted in the lecture.

中文翻译：

---

体外受精前的 O-280 循环编程

由于与长 GnRH 激动剂方案相比，GnRH 拮抗剂方案在卵巢刺激 (OS) 中越来越受欢迎：刺激持续时间缩短，促性腺激素消耗量减少，卵巢过度刺激综合征 (OHSS) 发生率降低，而不影响交付率。尽管与 GnRH 拮抗剂方案相关的明显好处，长 GnRH 激动剂方案允许更灵活和受控的卵母细胞检索时间表：这对于希望在自己方便的情况下接受生殖治疗的患者和 IVF 都很重要诊所。周期调度不仅可以更平均地分配工作量，还可以避免在周末进行绝大多数卵母细胞检索。为了规避这个缺点，已提倡使用口服避孕药 (OCP) 作为使用 GnRH 拮抗剂方案的 IVF 周期的编程方法。尽管已发表的证据清楚地表明了这种编程方法的负面影响，但它仍然在全球范围内广泛使用。然而，还有其他安排取卵的可能性，例如使用雌二醇、GnRH 拮抗剂的预处理和其他方法。这些选项将在讲座中突出显示。GnRH拮抗剂的预处理和其他方法。这些选项将在讲座中突出显示。GnRH拮抗剂的预处理和其他方法。这些选项将在讲座中突出显示。