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COVID-19 Vaccine Uptake Among Patients With Systemic Lupus Erythematosus in the American Midwest: The Lupus Midwest Network (LUMEN).
The Journal of Rheumatology ( IF 3.6 ) Pub Date : 2022-07-01 , DOI: 10.3899/jrheum.220220
Baptiste Chevet 1 , Gabriel Figueroa-Parra 2 , Jeffrey X Yang 3 , Cassondra A Hulshizer 4 , Tina M Gunderson 4 , Stephanie Q Duong 4 , Michael S Putman 5 , Kamil E Barbour 6 , Cynthia S Crowson 7 , Alí Duarte-García 8
Affiliation  

OBJECTIVE Patients with systemic lupus erythematosus (SLE) are at higher risk of poor outcomes from coronavirus disease 2019 (COVID-19). The vaccination rate among such patients is unknown. We aimed to assess COVID-19 vaccine uptake among patients with SLE. METHODS We included 342 patients with SLE from the Lupus Midwest Network (LUMEN) and 350 age-, sex-, race-, and county-matched comparators. Vaccination uptake for influenza, pneumococcal, and zoster vaccines before pandemic restrictions began (up to February 29, 2020) was assessed. First-dose COVID-19 vaccine uptake was electronically retrieved and manually ascertained (December 15, 2020, to July 31, 2021). Time to COVID-19 vaccination, demographics, SLE manifestations, medications, Charlson Comorbidity Index, Area Deprivation Index, and Rural-Urban Commuting Area codes were compared. RESULTS On July 31, 2021, 83.3% of patients with SLE and 85.5% of comparators were vaccinated against COVID-19. The COVID-19 vaccination rates were similar among SLE and comparators (hazard ratio 0.93, 95% CI 0.79-1.10). Unvaccinated patients with SLE were more likely than vaccinated patients to be men (27.3% vs 14.1%), younger (mean age 54.1 vs 58.8 yrs), have a shorter SLE duration (median 7.3 vs 10.7 yrs), and be less frequently vaccinated with influenza and pneumococcal vaccines. CONCLUSION Patients with SLE in the Lupus Midwest Network had similar COVID-19 vaccination uptake as matched comparators, most of whom were vaccinated early when the vaccine became available. One in 6 patients with SLE remain unvaccinated.

中文翻译:


美国中西部系统性红斑狼疮患者的 COVID-19 疫苗接种情况:中西部狼疮网络 (LUMEN)。



目的 系统性红斑狼疮 (SLE) 患者因 2019 年冠状病毒病 (COVID-19) 而出现不良预后的风险较高。此类患者的疫苗接种率尚不清楚。我们的目的是评估 SLE 患者对 COVID-19 疫苗的接种情况。方法 我们纳入了来自中西部狼疮网络 (LUMEN) 的 342 名 SLE 患者和 350 名年龄、性别、种族和县匹配的对照者。对大流行限制开始前(截至 2020 年 2 月 29 日)流感、肺炎球菌和带状疱疹疫苗的接种情况进行了评估。第一剂 COVID-19 疫苗接种情况通过电子方式检索并手动确定(2020 年 12 月 15 日至 2021 年 7 月 31 日)。比较了 COVID-19 疫苗接种时间、人口统计、SLE 表现、药物、查尔森合并症指数、地区剥夺指数和城乡通勤区代码。结果 截至 2021 年 7 月 31 日,83.3% 的 SLE 患者和 85.5% 的对照者接种了 COVID-19 疫苗。 SLE 和对照组之间的 COVID-19 疫苗接种率相似(风险比 0.93,95% CI 0.79-1.10)。未接种疫苗的 SLE 患者比接种疫苗的患者更有可能是男性(27.3% vs 14.1%)、更年轻(平均年龄 54.1 vs 58.8 岁)、SLE 持续时间较短(中位 7.3 vs 10.7 岁),并且接种疫苗的频率较低流感和肺炎球菌疫苗。结论 狼疮中西部网络中的 SLE 患者与匹配的对照者具有相似的 COVID-19 疫苗接种率,其中大多数人在疫苗上市时就尽早接种了疫苗。六分之一的 SLE 患者仍未接种疫苗。
更新日期:2022-07-01
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