Abstract

We investigated the association of MMP-9 rs1056628 and rs17576 polymorphisms with breast cancer (BC) relapse in a cohort of prospectively observed BC patients. The polymorphisms were genotyped in 200 BC subjects with(case) and without(control) relapse by Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) method. A significant association was found between the rs1056628C allele and increased risk of BC relapse (OR = 1.8, P = 0.006). Also, rs17576 allele and genotypes were shown protective effects against BC relapse. Increased risk of relapse was observed in haplotype CG (OR = 2.1, P = 0.001). Our results suggest for the first time that rs1056628 and rs17576 polymorphisms may influence BC relapse.

摘要

我们在一组前瞻性观察的 BC 患者中调查了MMP-9 rs1056628 和 rs17576 多态性与乳腺癌 (BC) 复发的关联。采用四引物扩增难治性突变系统-聚合酶链式反应（T-ARMS-PCR）方法对200名有（病例）和无（对照）复发的BC受试者的多态性进行基因分型。rs1056628C 等位基因与 BC 复发风险增加之间存在显着关联（OR = 1.8，P  = 0.006）。此外，rs17576 等位基因和基因型显示出对 BC 复发的保护作用。在单倍型 CG 中观察到复发风险增加（OR = 2.1，P  = 0.001）。我们的研究结果首次表明 rs1056628 和 rs17576 多态性可能影响 BC 复发。