Patients with diabetes mellitus are at risk for micro- and macrovascular complications that are responsible for a substantial part of the individual health burden and socio-economic costs. Therefore, implementable risk scores are needed to improve targeted prevention for patients that are particularly susceptible to complications. The “epigenetic clock” estimates an individual’s biological age using DNA methylation profiles and was previously shown to be associated with morbidity and mortality.

中文翻译：

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DNA 甲基化年龄加速、2 型糖尿病及其并发症：柏林衰老研究 II (BASE-II) 的横断面和纵向数据

糖尿病患者存在微血管和大血管并发症的风险，这些并发症是个人健康负担和社会经济成本的很大一部分。因此，需要可实施的风险评分来改善对特别容易出现并发症的患者的针对性预防。“表观遗传时钟”使用 DNA 甲基化谱估计个体的生物学年龄，之前已证明与发病率和死亡率有关。