Drug Delivery and Translational Research ( IF 5.7 ) Pub Date : 2022-07-01 , DOI: 10.1007/s13346-022-01198-3 Purushottam Suryavanshi 1 , Vishal Sharad Chaudhari 1 , Subham Banerjee 1
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Pharmacotherapy has become more focused on the personalized treatment of patients with various diseases. This field of pharmacology and pharmacogenomics focuses on developing drug delivery systems designed to address the unique characteristics of individual patients. Three-dimensional printing technology can be used to fabricate personalized drug delivery systems with desired release properties according to patient needs. Norfloxacin (NOR)-loaded micropellets (MPs) were fabricated and filled inside a stereolithography (SLA) 3D printing technology–mediated hollow capsular device in accordance with a standard size of 09 (8.4 mm length × 2.70 mm diameter). The prepared 3D-printed hollow capsular device filled with pristine NOR and NOR-loaded MPs were characterized in terms of both in vitro and in vivo means. MPs with the particle size distribution of 1540.0 ± 26 µm showed 95.63 ± 2.0% NOR content with pellet-shaped surface morphology. The in vitro release profile showed an initial lag phase of approximately 30 min, followed by the sustained release of NOR from MPs from the 3D-printed hollow capsular device. The pharmacokinetic profile showed prolonged Tmax, AUC, and evidence of good RBA of NOR compared to pure NOR after a single oral administration in the experimental animal model. The overall results confirm the feasibility of SLA-mediated 3D printing technology for preparing customized solid oral unit dosage carriers that can be filled with pure NOR- and NOR-loaded MPs with controlled-release delivery features.
Graphical abstract
中文翻译：
定制的 3D 打印空心胶囊装置，填充诺氟沙星微丸，用于控释递送
药物治疗越来越注重对各种疾病患者的个性化治疗。该药理学和药物基因组学领域专注于开发旨在解决个体患者独特特征的药物输送系统。三维打印技术可用于根据患者需要制造具有所需释放特性的个性化药物输送系统。根据标准尺寸 09（8.4 毫米长 × 2.70 毫米直径），制造并填充了载有诺氟沙星 (NOR) 的微丸 (MP) 并填充在立体光刻 (SLA) 3D 打印技术介导的中空胶囊装置中。制备的充满原始 NOR 和装载 NOR 的 MP 的 3D 打印空心胶囊装置在体外和体内手段方面进行了表征。粒径分布为 1540.0 ± 26 µm 的 MP 显示出 95.63 ± 2.0% 的 NOR 含量，具有颗粒状表面形态。体外释放曲线显示初始滞后阶段约为 30 分钟，随后从 3D 打印的空心胶囊装置的 MP 中持续释放 NOR。药代动力学特征显示延长在实验动物模型中单次口服给药后，与纯 NOR 相比，NOR 的T max、AUC 和良好 RBA 的证据。总体结果证实了 SLA 介导的 3D 打印技术制备定制固体口服单位剂量载体的可行性，这些载体可以填充具有控释递送功能的纯 NOR 和装载 NOR 的 MP。
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