Metabolic reprogramming is a hallmark of cancer progression. Metabolic activity supports tumorigenesis and tumor progression, allowing cells to uptake essential nutrients from the environment and use the nutrients to maintain viability and support proliferation. The metabolic pathways of malignant cells are altered to accommodate increased demand for energy, reducing equivalents, and biosynthetic precursors. Activated oncogenes coordinate with altered metabolism to control cell-autonomous pathways, which can lead to tumorigenesis when abnormalities accumulate. Clinical and preclinical studies have shown that targeting metabolic features of hematologic malignancies is an appealing therapeutic approach. This review provides a comprehensive overview of the mechanisms of metabolic reprogramming in hematologic malignancies and potential therapeutic strategies to target cancer metabolism.

中文翻译：

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血液系统恶性肿瘤中的代谢重编程：进展和临床前景

代谢重编程是癌症进展的标志。代谢活动支持肿瘤发生和肿瘤进展，使细胞能够从环境中吸收必需的营养物质，并利用这些营养物质来维持活力和支持增殖。恶性细胞的代谢途径发生改变，以适应能量、减少当量和生物合成前体的需求增加。激活的癌基因与代谢改变相协调，以控制细胞自主途径，当异常积累时，这可能导致肿瘤发生。临床和临床前研究表明，针对血液恶性肿瘤的代谢特征是一种有吸引力的治疗方法。