Rheumatoid arthritis (RA) has plagued physicians and patients for years due to the lack of targeted treatment. In this study, inspired by the commonality between rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and cancer cells, the therapeutic effects of cold air plasma (CAP) on RA are studied systematically and thoroughly. In/ex vivo results show that CAP with the proper dosage significantly relieves symptoms including synovial hyperplasia, inflammatory infiltration, and angiogenesis and eliminates the root cause by triggering the self-antioxidant capability of the surrounding tissue. The mechanism on the molecular and cellular level is also revealed that the spontaneous reactive oxygen species (ROS) cascade induces the mitochondrial apoptosis pathway on RA-FLS. This study reveals a new strategy for targeted treatment of RA and the mechanistic study provides the theoretical foundation for future development of plasma medicine.

中文翻译：

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冷空气等离子体通过线粒体凋亡途径改善类风湿关节炎

由于缺乏靶向治疗，类风湿性关节炎 (RA) 多年来一直困扰着医生和患者。本研究受类风湿性关节炎成纤维细胞样滑膜细胞（RA-FLS）与癌细胞共性的启发，系统深入地研究了冷空气等离子体（CAP）对RA的治疗作用。体内/体外结果表明，适当剂量的 CAP 可显着缓解滑膜增生、炎症浸润和血管生成等症状，并通过触发周围组织的自身抗氧化能力消除根本原因。分子和细胞水平上的机制也揭示了自发活性氧（ROS）级联诱导RA-FLS上的线粒体凋亡途径。