Background: 

Benign neonatal hemangiomatosis (BNH) is a rare, self-limiting subtype of infantile hemangiomas (IHs), in which infants with multiple cutaneous hemangiomas lack visceral involvement. Other subtypes of IHs exist that may mimic BNH and can be life-threatening depending on hemangioma location and size.

Clinical Findings: 

At birth, a 29⁵/₇-week preterm female presented with several pinhead-sized pink papules distributed throughout her body. At 10 days of age, the patient had 12 enlarged domed-shaped red papules in a generalized distribution throughout her body. Over several weeks, the number and size of the domed-shaped red papules continued to increase to a total of 26 located on the head, chest, abdomen, back, legs and arms. They were of firm consistency with both smooth and lobulated surfaces.

Primary Diagnosis: 

A diagnosis of BNH was made after extensive workup did not reveal any extracutaneous hemangiomas.

Interventions: 

Due to the lack of extracutaneous involvement and low-risk location/size of hemangiomas in our patient, no interventions were pursued and an observation-only approach was implemented.

Outcomes: 

The patient remained stable while followed up over 8 months, with the size of the hemangiomas only increasing slightly in proportion to the patient's natural body growth.

Practice Recommendations: 

Given the life-threatening nature of certain hemangioma subtypes, it is important to implement a proper workup and subtype diagnosis as early as possible in any infant with multiple hemangiomas.

中文翻译：

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良性新生儿血管瘤病

背景： 

良性新生儿血管瘤病 (BNH) 是一种罕见的自限性婴儿血管瘤 (IH) 亚型，其中患有多发性皮肤血管瘤的婴儿缺乏内脏受累。IH 的其他亚型可能与 BNH 相似，并且可能危及生命，具体取决于血管瘤的位置和大小。

临床发现： 

出生时，一名 29 岁⁵ / ₇周的早产女性全身出现数个针头大小的粉红色丘疹。在 10 日龄时，患者全身出现 12 个扩大的圆顶形红色丘疹，呈广泛分布。数周后，圆顶形红色丘疹的数量和大小持续增加，位于头部、胸部、腹部、背部、腿部和手臂的总数达到 26 个。它们与光滑和分叶状表面都具有牢固的一致性。

初步诊断： 

在广泛检查未发现任何皮外血管瘤后，诊断为 BNH。

干预措施： 

由于我们的患者没有皮肤外受累和血管瘤的低风险位置/大小，因此未进行任何干预，仅实施观察方法。

结果： 

患者在 8 个月的随访中保持稳定，血管瘤的大小仅与患者的自然身体生长成比例地略有增加。

实践建议： 

鉴于某些血管瘤亚型具有危及生命的性质，因此对患有多发性血管瘤的任何婴儿尽早实施适当的检查和亚型诊断非常重要。