The homeless population in the United States is rapidly aging, with a parallel increase in Alzheimer’s disease and related dementia (ADRD). During an evolving pandemic that jeopardizes employment and housing, assessing the relationship between ADRD and homelessness is critical since the latter is potentially intervenable. The objective of this study is to review the literature and determine whether there is an association between homelessness and dementia risk. A systematic review of existing studies was conducted through PubMED, SCOPUS, and EMBASE among others. Of the 228 results found, nine met inclusion criteria. Homeless studies mainly centered on veteran populations (n = 6/9). There is a complex relationship suggesting homelessness as a risk for and consequence of ADRD but also co-occurrence with psychiatric disorders, substance abuse, and traumatic injuries. Future studies should employ enumeration surveys with modular longitudinal tracking and measure social determinants of health, discrimination, chronic stress, and mood disorders.

美国的无家可归人口正在迅速老龄化，阿尔茨海默氏病和相关痴呆症 (ADRD) 的发病率也在同步上升。在危及就业和住房的不断发展的大流行期间，评估 ADRD 与无家可归之间的关系至关重要，因为后者可能是可以干预的。本研究的目的是回顾文献并确定无家可归与痴呆症风险之间是否存在关联。通过 PubMED、SCOPUS 和 EMBASE 等对现有研究进行了系统回顾。在找到的 228 个结果中，有 9 个符合纳入标准。无家可归者研究主要集中在退伍军人群体（n= 6/9）。存在一种复杂的关系，表明无家可归是 ADRD 的风险和后果，但也与精神疾病、药物滥用和外伤同时发生。未来的研究应该采用具有模块化纵向跟踪的枚举调查，并测量健康、歧视、慢性压力和情绪障碍的社会决定因素。