Tunable Emissive Ir(III) Benzimidazole-quinoline Hybrids as Promising Theranostic Lead Compounds,ChemMedChem

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Tunable Emissive Ir(III) Benzimidazole-quinoline Hybrids as Promising Theranostic Lead Compounds
ChemMedChem ( IF 3.6 ) Pub Date : 2022-06-29 , DOI: 10.1002/cmdc.202200244
Marta Redrado ₁ , Miriam Miñana ₁ , Michael P Coogan ₂ , M Concepción Gimeno ₁ , Vanesa Fernández-Moreira ₁

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Two tuneable emissive Ir(III) benzimidazole-quinoline complexes were developed and their suitability as cell imaging agents within both, fluorescence and time resolved microscopy was demonstrated. Moreover, the high cytotoxicity and photocytotoxicity displayed in A549 lung cancer cells promote them as good candidates towards the search of the next generation of theranostic agents.

中文翻译：

可调发射性 Ir(III) 苯并咪唑-喹啉杂化物作为有前途的治疗先导化合物

开发了两种可调谐发射Ir(III) 苯并咪唑-喹啉配合物，并证明了它们在荧光和时间分辨显微镜中作为细胞成像剂的适用性。此外，A549 肺癌细胞表现出的高细胞毒性和光细胞毒性促使它们成为寻找下一代治疗诊断药物的良好候选者。

更新日期：2022-06-29

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