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Imaging Mass Cytometry Reveals Predominant Innate Immune Signature and Endothelial–Immune Cell Interaction in Juvenile Myositis Compared to Lupus Skin
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-06-28 , DOI: 10.1002/art.42283
Jessica L Turnier 1 , Christine M Yee 2 , Jacqueline A Madison 3 , Syed M Rizvi 2 , Celine C Berthier 4 , Fei Wen 2 , J Michelle Kahlenberg 5
Affiliation  

Cutaneous inflammation can signal disease in juvenile dermatomyositis (DM) and childhood-onset systemic lupus erythematosus (cSLE), but we do not fully understand cellular mechanisms of cutaneous inflammation. In this study, we used imaging mass cytometry to characterize cutaneous inflammatory cell populations and cell–cell interactions in juvenile DM as compared to cSLE.

中文翻译:

与狼疮皮肤相比,成像质谱流式细胞术揭示了幼年性肌炎的主要先天免疫特征和内皮-免疫细胞相互作用

皮肤炎症可能是幼年型皮肌炎 (DM) 和儿童期发病的系统性红斑狼疮 (cSLE) 疾病的信号,但我们并不完全了解皮肤炎症的细胞机制。在这项研究中,我们使用成像质量流式细胞术来表征与 cSLE 相比,幼年 DM 中的皮肤炎症细胞群和细胞-细胞相互作用。
更新日期:2022-06-28
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