Human susceptibility to coronary artery disease: lessons from chimpanzee resilience,Nature Reviews Cardiology

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Human susceptibility to coronary artery disease: lessons from chimpanzee resilience
Nature Reviews Cardiology ( IF 41.7 ) Pub Date : 2022-06-29 , DOI: 10.1038/s41569-022-00738-1
Gemma A Figtree _{1,

2,

3} , Jason C Kovacic _{4,

5,

6} , Helen M McGuire ₃

Affiliation

Important lessons about human susceptibility to coronary atherosclerosis can be learned from the relative resilience of chimpanzees to coronary artery disease (CAD), despite their higher baseline plasma levels of LDL cholesterol and lipoprotein(a) than in humans. Evolutionary pressure and hyper-reactive T cells might have a role in the unique susceptibility of humans to CAD.

中文翻译：

人类对冠状动脉疾病的易感性：黑猩猩复原力的教训

尽管黑猩猩的 LDL 胆固醇和脂蛋白 (a) 基线血浆水平高于人类，但可以从黑猩猩对冠状动脉疾病 (CAD) 的相对复原力中学到关于人类对冠状动脉粥样硬化易感性的重要教训。进化压力和高反应性 T 细胞可能在人类对 CAD 的独特易感性中起作用。

更新日期：2022-06-29

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