Abstract

Introduction

Approximately 25% of the patients with hospital acquired anemia (HAA) develop moderate to severe HAA during hospitalization. This is related to an increased risk of prolonged stay, readmission and mortality. The primary aim was during one year to characterize a population with very frequent phlebotomies based on a university hospital in the Capital Region of Denmark and the related general practitioners

Material and methods

We conducted a retrospective cohort study using administrative data on phlebotomies from 1 January 2019 to 31 December 2019 analyzed at a university hospital.

Results

A total of 203,811 patients had 10,083,207 requisitions and 1,373,013 tubes. One percent, 1985 patients, had an extreme of frequent phlebotomies >60 tubes and formed the basis for the study population. The study population was significantly older as compared to the excluded patients (<60 tubes) (mean 65.7 vs. 51.6 years, p < .001).The likelihood of hemoglobin decrease per 100 mL blood drawn were calculated at four levels of decreases: Hemoglobin decrease of 2 mmol/L (adjusted OR; 95%; 2.03, CI 1.79–2.31), hemoglobin decrease of 3 mmol/L (adjusted OR; 95%, 1.36, CI 1.28–1.45), hemoglobin decrease of 4 mmol/L, (adjusted OR; 95%, 1.27, CI 1.19–1.35) and hemoglobin decrease of 5 mmol/L, (adjusted OR; 95% 1.22, CI 1.13–1.31).

Conclusions

Moderate to severe HAA occurred in a limited group with excessive many phlebotomies. It was a worrisome trend that the frailest patients had the highest risk of developing HAA.

中文翻译：

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2019 年丹麦首都地区一所大学医院患者的医院获得性贫血和附属全科医学

摘要

介绍

大约 25% 的医院获得性贫血 (HAA) 患者在住院期间发展为中度至重度 HAA。这与延长住院、再入院和死亡的风险增加有关。主要目的是在一年内根据丹麦首都地区的一所大学医院和相关的全科医生来描述经常采血的人群

材料与方法

我们使用在大学医院分析的 2019 年 1 月 1 日至 2019 年 12 月 31 日放血的行政数据进行了一项回顾性队列研究。

结果

共有203,811名患者有1,0083,207份申请和1,373,013管。1985 名患者中有 1% 的患者频繁采血 > 60 根插管，这构成了研究人群的基础。与排除的患者（<60 支试管）相比，研究人群的年龄显着增加（平均 65.7 岁与 51.6 岁，p  < .001）。每 100 毫升血液中血红蛋白降低的可能性按四个降低水平计算：降低 2 mmol/L（调整后的 OR；95%；2.03，CI 1.79-2.31），血红蛋白降低 3 mmol/L（调整后的 OR；95%，1.36，CI 1.28-1.45），血红蛋白降低 4 mmol/L ,（调整后的 OR；95%，1.27，CI 1.19–1.35）和血红蛋白降低 5 mmol/L，（调整后的 OR；95% 1.22，CI 1.13–1.31）。

结论

中度至重度 HAA 发生在有过多放血的有限组中。最虚弱的患者发生 HAA 的风险最高，这是一个令人担忧的趋势。