R-spondins are critical regulators of gastric epithelial cells, with Lgr5 receptor historically considered as their main signaling transducer. Recent work by Wizenty et al (2022) now revealed distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.

中文翻译：

---

胃中的 R-spondin 信号传导：峡部 Lgr4 规则

R-spondins 是胃上皮细胞的关键调节因子，Lgr5 受体历来被认为是其主要信号转导器。Wizenty 等人 (2022) 最近的工作揭示了 Lgr4 和 Lgr5 在幽门螺杆菌感染后指导腺体重建中的不同作用，为胃再生过程中 Rspo 信号传导的复杂性提供了新的线索，并提出了有关胃窦干细胞层次结构的问题。