An Activatable 19F MRI Molecular Probe for Sensing and Imaging of Norepinephrine,ChemistryOpen

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An Activatable 19F MRI Molecular Probe for Sensing and Imaging of Norepinephrine
ChemistryOpen ( IF 2.5 ) Pub Date : 2022-06-28 , DOI: 10.1002/open.202200110
Lingxuan Li ₁ , Ao Li ₁ , Yaying Lin ₁ , Dongxia Chen ₁ , Bilun Kang ₁ , Hongyu Lin ₁ , Jinhao Gao ₁

Affiliation

A small-molecular ¹⁹F MRI probe (NRFP) was developed by conjugating a fluorine-containing moiety and a paramagnetic Gd chelate through a NE-responsive aromatic thiocarbonate linkage, which allows for detection of NE using ¹⁹F NMR/MRI. Its capacity and specificity for sensing and imaging NE have been demonstrated by a series of in vitro, ex vivo, and in vivo experiments.

中文翻译：

用于去甲肾上腺素传感和成像的可激活 19F MRI 分子探针

小分子¹⁹ F MRI 探针(NRFP) 是通过 NE 响应性芳香族硫代碳酸酯键连接含氟部分和顺磁性 Gd 螯合物而开发的，可使用¹⁹ F NMR/MRI 检测 NE。其传感和成像 NE 的能力和特异性已通过一系列体外、离体和体内实验得到证明。

更新日期：2022-06-28

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