The migration of perchlorate into dairy products through water or detergent is becoming increasingly serious. Spatiotemporal profiles of lipid nutrients associated with perchlorate response were investigated by spatial multi-omics of goat milk. In response to perchlorate accumulation, lipoprotein lipase activity was inhibited in glycerolipid metabolism, thereby resulting in the excessive accretion of triglycerides. Goat milk was selected as the test matrix and conducted to simulate the biological cumulation of perchlorate and evaluate effects of different dietary perchlorate levels (0.0–2.0 mg/kg) on nutritional quality of goat milk. Perchlorate altered phospholipase A₂ expression level, affected glycerophospholipid metabolism thus triggered significant changes in phosphatidylcholine (23.35–31.88 μg/mL). Excess triacylglycerol accumulation (3259–6032 μg/mL) caused by perchlorate was due to the inhibition of glycerolipid metabolism mediated by lipoprotein lipase. The study indicated that dietary perchlorate exposure resulted in the decline of nutritional quality in goat milk, which indirectly posed a serious threat to the health of consumers.

高氯酸盐通过水或洗涤剂迁移到乳制品中变得越来越严重。通过山羊奶的空间多组学研究了与高氯酸盐反应相关的脂质营养素的时空分布。响应于高氯酸盐的积累，脂蛋白脂肪酶活性在甘油脂代谢中受到抑制，从而导致甘油三酯的过度积累。选择山羊奶作为测试基质，模拟高氯酸盐的生物累积，评估不同日粮高氯酸盐水平（0.0-2.0 mg/kg）对山羊奶营养品质的影响。高氯酸盐改变的磷脂酶 A ₂表达水平，影响甘油磷脂代谢，从而引发磷脂酰胆碱的显着变化（23.35-31.88 μg/mL）。由高氯酸盐引起的过量三酰基甘油积累（3259–6032 μg/mL）是由于脂蛋白脂肪酶介导的甘油脂代谢的抑制。研究表明，膳食中高氯酸盐暴露导致羊奶营养品质下降，间接对消费者健康构成严重威胁。