Physical hydrogels of pure chitosan preserve the natural properties of chitosan, and therefore are ideal candidates for wound dressing applications, however, their poor mechanical strength severely limits their application. In addition, chitosan dressings tend to adhere to the wounds, making their change difficult. Here physical hydrogels of pure chitosan were prepared by first dissolving chitosan in an alkaline aqueous solution, followed by thermal gelling and solvent change. The gels exhibited better mechanical properties than the gels prepared previously. They were soluble in diluted acetic acid, making them on-demand dissoluble. When used as wound dressing and changed by mechanical debridement, the gels achieved a faster wound closure than gauze. An even faster wound closure was achieved when they were changed by dissolution with acetic acid solution. Besides a faster healing, the on-demand dissoluble dressing could also reduce the formation of scars and reestablish the normal anatomy and function of the skin.

纯壳聚糖的物理水凝胶保留了壳聚糖的天然特性，因此是伤口敷料应用的理想选择，但其较差的机械强度严重限制了其应用。此外，壳聚糖敷料容易粘附在伤口上，难以更换。在这里，通过首先将壳聚糖溶解在碱性水溶液中，然后进行热凝胶化和溶剂更换来制备纯壳聚糖的物理水凝胶。凝胶表现出比先前制备的凝胶更好的机械性能。它们可溶于稀醋酸中，使它们按需溶解。当用作伤口敷料并通过机械清创进行更换时，凝胶比纱布更快地闭合伤口。当通过用乙酸溶液溶解改变它们时，实现了更快的伤口闭合。除了更快的愈合，按需可溶性敷料还可以减少疤痕的形成并重建皮肤的正常解剖结构和功能。