Zhang et al. demonstrate that the adenosine deaminase ADAR1 prevents responsiveness to immune checkpoint blockade (ICB) through acting on cellular Z-nucleic acids, and show inducing Z-nucleic acid formation can induce tumour sensitivity to ICB.

中文翻译：

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Z-核酸促进免疫治疗

张等人。证明腺苷脱氨酶 ADAR1 通过作用于细胞 Z-核酸来防止对免疫检查点阻断 (ICB) 的反应，并表明诱导 Z-核酸形成可以诱导肿瘤对 ICB 的敏感性。