Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications,ACS Sensors

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Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications
ACS Sensors ( IF 8.2 ) Pub Date : 2022-06-28 , DOI: 10.1021/acssensors.2c00940
Yao Meng ₁ , Fangming Chen ₁ , Chunsheng Wu ₁ , Steffi Krause ₂ , Jian Wang _{1,

3} , De-Wen Zhang _{1,

3}

Affiliation

The light-addressable electrochemical sensor (LAES) is a recently emerged bioanalysis technique combining electrochemistry with the photoelectric effect in a semiconductor. In an LAES, a semiconductor substrate is illuminated locally to generate charge carriers in a well-defined area, thereby confining the electrochemical process to a target site. Benefiting from the unique light addressability, an LAES can not only detect multiple analytes in parallel within a single sensor plate but also act as a bio(chemical) imaging sensor to visualize the two-dimensional distribution of specific analytes. An LAES usually has three working modes: a potentiometric mode using light-addressable potentiometric sensors (LAPS) and an impedance mode using scanning photoinduced impedance microscopy (SPIM), while an amperometric mode refers to light-addressable electrochemistry (LAE) and photoelectrochemical (PEC) sensing. In this review, we describe the detection principles of each mode of LAESs and the concept of light addressability. In addition, we highlight the recent progress and advance of LAESs in spatial resolution, sensor system design, multiplexed detection, and bio(chemical) imaging applications. An outlook on current research challenges and future prospects is also presented.

中文翻译：

面向空间分辨生物传感和成像应用的光寻址电化学传感器

光寻址电化学传感器 (LAES) 是最近出现的一种生物分析技术，将电化学与半导体中的光电效应相结合。在 LAES 中，半导体衬底被局部照射以在明确定义的区域中产生电荷载流子，从而将电化学过程限制在目标位置。得益于独特的光寻址能力，LAES 不仅可以在单个传感器板上并行检测多种分析物，还可以作为生物（化学）成像传感器来可视化特定分析物的二维分布。LAES 通常具有三种工作模式：使用光寻址电位传感器 (LAPS) 的电位模式和使用扫描光感应阻抗显微镜 (SPIM) 的阻抗模式，而安培模式是指光可寻址电化学 (LAE) 和光电化学 (PEC) 传感。在这篇综述中，我们描述了 LAES 每种模式的检测原理和光可寻址性的概念。此外，我们重点介绍了 LAES 在空间分辨率、传感器系统设计、多路检测和生物（化学）成像应用方面的最新进展和进展。还提出了对当前研究挑战和未来前景的展望。

更新日期：2022-06-28

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