Optimized design of Surface plasmon resonance (SPR) based biosensor in terms of different metal choices and prisms are presented to the first time for the high precision detection of human blood group in near infrared wavelength range. The results are well compared with the earlier published gold coated silicon biosensor chip while discussing the pros and cons of various prism/metal choices. In this study buffer layer onto SPR active metal has been deployed to avoid the oxidation problem and contamination issue related with blood samples. Refractive index of blood samples has been considered in theoretical model based on the experimental data. Si prism has been found to be the best choice as a substrate material with combination of Al as a SPR active metal for blood group identification analysis. SPR dip slope (S), detection accuracy (D.A.) and blood group discrimination factor ( δθSPR\delta \theta _{\textit {SPR}} ) have been studied with respect to different metal choices with their suitability to the next generation biosensor applications.

中文翻译：

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用于人类血型识别的表面等离子共振生物传感器芯片中不同金属和棱镜选择的数值研究


首次提出了基于表面等离子共振（SPR）的生物传感器在不同金属选择和棱镜方面的优化设计，用于近红外波长范围内人体血型的高精度检测。结果与早期发布的镀金硅生物传感器芯片进行了很好的比较，同时讨论了各种棱镜/金属选择的优缺点。在本研究中，在 SPR 活性金属上部署了缓冲层，以避免与血液样本相关的氧化问题和污染问题。基于实验数据的理论模型考虑了血液样本的折射率。已发现Si棱镜是与Al组合作为SPR活性金属用于血型鉴定分析的基底材料的最佳选择。针对不同金属选择及其对下一代生物传感器应用的适用性，研究了 SPR 倾角斜率 (S)、检测精度 (DA) 和血型辨别因子 ( δθSPR\delta \theta _{\textit {SPR}} ) 。