BACKGROUND The Integrated Liver Inflammatory Score (ILIS), which includes 5 serum indicators (albumin, bilirubin, neutrophil count, alpha-fetoprotein [AFP], and alkaline phosphatase [ALP]), is a novel inflammation-based predictive model associated with poor survival in hepatocellular carcinoma (HCC) patients. Our study aimed to assess the prognostic value of ILIS in HCC patients undergoing radical hepatectomy and establish a nomogram and artificial neural network based on their ILIS scores. MATERIAL AND METHODS This multicenter retrospective study included patients from 2 institutions from 2007 to 2017. Independent risk factors associated with Recurrence-free survival (RFS) and overall survival (OS) were identified through univariate and multifactor analysis in the training and validation groups, respectively. Afterward, column line graphs and artificial neural networks (ANN) were constructed and validated using the validation group. RESULTS A total of 432 patients were included in this study (275 in the training group and 157 in the validation group). In both cohorts, ILIS was correlated with pathological features such as tumor size, degree of differentiation, Child-Pugh class classification, and BCLC staging. Moreover, ILIS was identified as an independent risk factor for OS. ILIS-based nomograms and artificial neural networks also showed the prognostic value of ILIS. CONCLUSIONS Preoperative ILIS is an independent and effective predictor of prognosis in HCC patients treated with radical hepatectomy, as shown by the fact that higher ILIS are associated with worse patient prognosis. We have also established nomograms and ANNs that predict HCC prognosis with high accuracy.

中文翻译：

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肝细胞癌患者术前综合肝脏炎症评分的预后意义。

背景 综合肝脏炎症评分 (ILIS) 包括 5 个血清指标（白蛋白、胆红素、中性粒细胞计数、甲胎蛋白 [AFP] 和碱性磷酸酶 [ALP]），是一种新的基于炎症的预测模型，与生存率低相关在肝细胞癌（HCC）患者中。我们的研究旨在评估 ILIS 在接受根治性肝切除术的 HCC 患者中的预后价值，并根据他们的 ILIS 评分建立列线图和人工神经网络。材料和方法 这项多中心回顾性研究包括 2007 年至 2017 年来自 2 个机构的患者。通过单变量和多因素分析，分别在训练组和验证组中确定了与无复发生存期 (RFS) 和总生存期 (OS) 相关的独立危险因素. 之后，使用验证组构建和验证柱线图和人工神经网络（ANN）。结果 本研究共纳入 432 例患者（训练组 275 例，验证组 157 例）。在这两个队列中，ILIS 与肿瘤大小、分化程度、Child-Pugh 分级和 BCLC 分期等病理特征相关。此外，ILIS 被确定为 OS 的独立危险因素。基于 ILIS 的列线图和人工神经网络也显示了 ILIS 的预后价值。结论 术前 ILIS 是接受根治性肝切除术治疗的 HCC 患者预后的独立且有效的预测因子，正如较高的 ILIS 与较差的患者预后相关的事实所示。