SummaryUnderstanding metabolic dependencies and their therapeutic vulnerabilities is key to precision oncology. Malic enzyme 1 (ME1) is frequently overexpressed in cancers with protumorigenic effects. In contrast, consistent loss of ME1 expression in synovial sarcoma compared with other sarcomas indicates a unique ferroptosis liability for precision therapy in this form of cancer.See related article by Brashears et al., p. 3573

中文翻译：

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针对滑膜肉瘤中的铁死亡漏洞：一切都与 ME1 有关吗？

摘要了解代谢依赖性及其治疗脆弱性是精准肿瘤学的关键。苹果酸酶 1 (ME1) 在具有促肿瘤作用的癌症中经常过度表达。相比之下，与其他肉瘤相比，滑膜肉瘤中 ME1 表达持续缺失，表明这种癌症的精确治疗具有独特的铁死亡倾向。请参阅 Brashears 等人的相关文章，第 17 页。3573