Wastewater-based epidemiology (WBE) was applied to evaluate seasonal variations of the consumption of pharmaceuticals (i.e. antibiotics, NSAIDs, antiepileptics, antihypertensives and others), caffeine, alcohol and nicotine in Latvia throughout 2021. In addition, weekly variation of caffeine, nicotine and alcohol consumption was investigated. Pronounced seasonality was observed in the consumption of antibiotics and decongestants, as well as caffeine, nicotine and alcohol. Correlation with COVID-19 statistics was observed in the case of macrolide antibiotics and antiasthmatic salbutamol. Comparison of the estimated consumption values obtained using the WBE approach and the statistics revealed that the majority of compounds data are in good agreement except angiotensin II receptor blocker group antihypertensives where the most overestimated consumption values were observed.

基于废水的流行病学 (WBE) 被用于评估整个 2021 年拉脱维亚的药物（即抗生素、非甾体抗炎药、抗癫痫药、抗高血压药等）、咖啡因、酒精和尼古丁消费的季节性变化。此外，咖啡因、尼古丁的每周变化并调查了饮酒量。在抗生素和减充血剂以及咖啡因、尼古丁和酒精的消费中观察到明显的季节性。在大环内酯类抗生素和抗哮喘药沙丁胺醇的情况下，观察到与 COVID-19 统计数据的相关性。