The present study was focused on improving the supercritical fluid extraction process dedicated to the recovery of highly valuable extract from Silybum marianum seeds. At first, the process was tested using supercritical CO₂ at temperatures of 40 and 80 °C and pressures ranging from 100 to 300 bar. Obtained values were described using two literature models with acceptable agreement of experimental and calculated data. Further, the effect of the equipment design and process scale-up was investigated in four high-pressure units having volumes in the range from 280 mL to 40 L resulting in extraction yields up to 26 %. Based on the values of the parameters determined at the laboratory scale, the extraction process was successfully transferred to a semi-industrial scale. Finally, estimated costs for supercritical extract production in Poland for the year 2021 using a 1000 L high-pressure unit amounted to the price of 35.9 EUR per kg of extract.

本研究的重点是改进超临界流体萃取工艺，专门用于从水飞蓟种子中回收高价值的提取物。起初，该工艺使用超临界 CO _{2进行测试}在 40 和 80 °C 的温度和 100 至 300 bar 的压力范围内。使用两种文献模型描述获得的值，实验和计算数据具有可接受的一致性。此外，在体积范围为 280 mL 至 40 L 的四个高压装置中研究了设备设计和工艺放大的影响，导致提取率高达 26%。根据在实验室规模确定的参数值，提取过程成功地转移到半工业规模。最后，波兰 2021 年使用 1000 L 高压装置的超临界提取物生产成本估计为每公斤提取物 35.9 欧元的价格。