Purpose

Optic disc drusen (ODD) is an anatomical risk factor for nonarteritic anterior ischemic optic neuropathy (NA-AION). This study aimed to investigate the anatomical and vascular risk factors of patients with ODD-AION (ODD-associated NA-AION) and compare them with similar data from patients with nODD-AION (NA-AION without ODD).

Design

: Case-control study.

Methods

Thirty-four ODD-AION and 34 nODD-AION patients who had all been systematically optical coherence tomography scanned using a standardized ODD scanning protocol were retrospectively analyzed and compared regarding demographics, vascular risk factors, clinical characteristics, and specific optic nerve head anatomical characteristics.

Results

In patients with ODD-AION, the ODD were predominantly deeply located (82%) but with no significant difference in size (52% large, 48% small). When compared with nODD-AION patients, ODD-AION patients were significantly younger at the time of diagnosis (P = .012) and had fewer vascular risk factors (P = .015). The ODD-AION patients had significantly more peripapillary hyperreflective ovoid mass-like structures (PHOMS) (P < .001) and prelaminar hyperreflective lines (P < .001) as well as smaller Bruch's membrane opening diameters (P = .017) compared with nODD-AION patients. No significant differences were found between ODD-AION and nODD-AION patients regarding visual acuity, refraction, lamina cribrosa position, ganglion cell layer volume, or retinal nerve fiber layer thickness.

Conclusion

In ODD-AION, location of the ODD within the optic nerve head is important, while the size of the ODD is not. The ODD-AION and nODD-AION patients presented with distinctly different vascular risk factors and anatomical characteristics, establishing ODD and potentially also PHOMS as independent risk factors for developing NA-AION.

中文翻译：

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视盘玻璃疣相关前部缺血性视神经病变患者的视神经头解剖和血管危险因素

目的

视盘玻璃疣 (ODD) 是非动脉炎性前部缺血性视神经病变 (NA-AION) 的解剖学危险因素。本研究旨在调查 ODD-AION（ODD 相关的 NA-AION）患者的解剖学和血管危险因素，并将其与 nODD-AION 患者（无 ODD 的 NA-AION）的类似数据进行比较。

设计

:病例对照研究。

方法

回顾性分析并比较了 34 名 ODD-AION 和 34 名 nODD-AION 患者，这些患者均使用标准化的 ODD 扫描方案进行了系统光学相干断层扫描，并比较了人口统计学、血管危险因素、临床特征和特定视神经乳头解剖特征。

结果

在 ODD-AION 患者中，ODD 主要位于深部（82%），但大小无显着差异（52% 大，48% 小）。与 nODD-AION 患者相比，ODD-AION 患者在诊断时明显更年轻 ( P  = .012)，血管危险因素更少 ( P  = .015)。ODD-AION 患者的视乳头周围超反射卵圆形肿块样结构 (PHOMS) ( P < .001) 和层前超反射线 ( P < .001) 以及更小的 Bruch 膜开口直径 ( P ) 显着增加 = .017) 与 nODD-AION 患者相比。ODD-AION 和 nODD-AION 患者在视力、屈光度、筛板位置、神经节细胞层体积或视网膜神经纤维层厚度方面没有显着差异。

结论

在 ODD-AION 中，ODD 在视神经乳头内的位置很重要，而 ODD 的大小则不重要。ODD-AION 和 nODD-AION 患者表现出明显不同的血管危险因素和解剖特征，确定 ODD 和潜在的 PHOMS 作为发展 NA-AION 的独立危险因素。