Aims The influenza virus is an infectious disease with acute respiratory tract infections, caused secondary bacterial infections and death. In this study, we aimed to determine which predictors were associated with the need for high-flow nasal cannula oxygen therapy (HFNC) and transition to intensive care for influenza virus and also to compare single viral pathogens with multiple ones. Methods Inpatients under the age of 5 with influenza virus-related respiratory tract infections between November 2015 and March 2019 were included in the study. Demographic features, comorbidities, symptoms, secondary bacterial infection, need for HFNC and pediatric intensive care unit and respiratory support system, length of hospital stay, polymerase chain reaction tests were recorded. Results A total of 93 patients were included in the study. It was determined that 53.8% of the cases were male and 84.9% were under the age of 2. Comorbidities were present in 50.5% of the cases. Secondary bacterial pneumonia developed in 56.9% of the cases. Patients with secondary bacterial pneumonia had higher PICU need, HFNC need and hospital stay (p = 0.014, p ≤ 0.001 and p ≤ 0.001, respectively). Patients with comorbidity had longer hospital stays and a higher need for HFNC (p ≤ 0.001 and p = 0.001, respectively). Conclusions In this study, it was determined that especially comorbidity and secondary bacterial infection aggravated the clinical treatment of hospitalized patients. Therefore, it was concluded that patients with comorbidity should be followed closely and secondary bacterial pneumonia should be recognized and treated early.

中文翻译：

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5岁以下儿童流感病毒感染入院特征及结果

目的 流感病毒是一种急性呼吸道感染性疾病，可引起继发性细菌感染而死亡。在这项研究中，我们旨在确定哪些预测因素与需要高流量鼻导管氧疗 (HFNC) 和过渡到流感病毒重症监护相关，并比较单一病毒病原体与多种病毒病原体。方法将2015年11月至2019年3月期间发生流感病毒相关呼吸道感染的5岁以下住院患者纳入研究。记录人口学特征、合并症、症状、继发性细菌感染、对 HFNC 和儿科重症监护病房和呼吸支持系统的需求、住院时间、聚合酶链反应测试。结果共纳入93例患者。经确定，53.8% 的病例为男性，84.9% 为 2 岁以下。50.5% 的病例存在合并症。56.9% 的病例发生继发性细菌性肺炎。继发性细菌性肺炎患者的 PICU 需求、HFNC 需求和住院时间均较高（分别为 p = 0.014、p ≤ 0.001 和 p ≤ 0.001）。合并症患者的住院时间更长，对 HFNC 的需求更高（分别为 p ≤ 0.001 和 p = 0.001）。结论 本研究确定，尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。50.5% 的病例存在合并症。56.9% 的病例发生继发性细菌性肺炎。继发性细菌性肺炎患者的 PICU 需求、HFNC 需求和住院时间均较高（分别为 p = 0.014、p ≤ 0.001 和 p ≤ 0.001）。合并症患者的住院时间更长，对 HFNC 的需求更高（分别为 p ≤ 0.001 和 p = 0.001）。结论 本研究确定，尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。50.5% 的病例存在合并症。56.9% 的病例发生继发性细菌性肺炎。继发性细菌性肺炎患者的 PICU 需求、HFNC 需求和住院时间均较高（分别为 p = 0.014、p ≤ 0.001 和 p ≤ 0.001）。合并症患者的住院时间更长，对 HFNC 的需求更高（分别为 p ≤ 0.001 和 p = 0.001）。结论 本研究确定，尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。继发性细菌性肺炎患者的 PICU 需求、HFNC 需求和住院时间均较高（分别为 p = 0.014、p ≤ 0.001 和 p ≤ 0.001）。合并症患者的住院时间更长，对 HFNC 的需求更高（分别为 p ≤ 0.001 和 p = 0.001）。结论 本研究确定，尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。继发性细菌性肺炎患者的 PICU 需求、HFNC 需求和住院时间均较高（分别为 p = 0.014、p ≤ 0.001 和 p ≤ 0.001）。合并症患者的住院时间更长，对 HFNC 的需求更高（分别为 p ≤ 0.001 和 p = 0.001）。结论 本研究确定，尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。确定尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。确定尤其是合并症和继发性细菌感染加重了住院患者的临床治疗。因此得出结论，对合并症患者应密切随访，对继发性细菌性肺炎应早发现、早治疗。