Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics,Accounts of Chemical Research

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Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2022-06-24 , DOI: 10.1021/acs.accounts.2c00216
Kevin Jooß ₁ , John P McGee _{1,

2} , Neil L Kelleher ₁

Affiliation

Biology is driven by a vast set of molecular interactions that evolved over billions of years. Just as covalent modifications like acetylations and phosphorylations can change a protein’s function, so too can noncovalent interactions with metals, small molecules, and other proteins. However, much of the language of protein-level biology is left either undiscovered or inferred, as traditional methods used in the field of proteomics use conditions that dissociate noncovalent interactions and denature proteins.

中文翻译：

结构生物学和组成蛋白质组学融合的天然质谱分析

生物学是由数十亿年来进化的大量分子相互作用驱动的。正如乙酰化和磷酸化等共价修饰可以改变蛋白质的功能一样，与金属、小分子和其他蛋白质的非共价相互作用也可以改变蛋白质的功能。然而，蛋白质水平生物学的许多语言要么未被发现，要么被推断出来，因为蛋白质组学领域使用的传统方法使用解离非共价相互作用并使蛋白质变性的条件。

更新日期：2022-06-24

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